| Identification | Back Directory | [Name]
7H-Pyrazolo[4,3-d]pyrimidin-7-one, 3-ethyl-5-[5-[(4-ethyl-1-piperazinyl)sulfonyl]-2-(2-methoxyethoxy)-3-pyridinyl]-2,6-dihydro-2-(2-pyridinylmethyl)- | [CAS]
247580-98-9 | [Synonyms]
UK357903
UK-357903
UK 357903
7H-Pyrazolo[4,3-d]pyrimidin-7-one, 3-ethyl-5-[5-[(4-ethyl-1-piperazinyl)sulfonyl]-2-(2-methoxyethoxy)-3-pyridinyl]-2,6-dihydro-2-(2-pyridinylmethyl)- | [Molecular Formula]
C27H34N8O5S | [MDL Number]
MFCD07364025 | [MOL File]
247580-98-9.mol | [Molecular Weight]
582.67 |
| Hazard Information | Back Directory | [Uses]
UK 357903 is a selective inhibitor for phosphodiesterase 5 (PDE5), with IC50s of 1.7 and 714 nM, for PDE5 and PDE6. UK 357903 exhibits vasodilatory effects on the mesenteric and hindlimb vascular beds, and is potential for ameliorating erectile dysfunction[1]. | [IC 50]
PDE5: 1.7 nM (IC50); PDE6: 714 nM (IC50) | [References]
[1] Gardiner SM, et al., Haemodynamic effects of the selective phosphodiesterase 5 inhibitor, UK-357,903, in conscious SHR. Br J Pharmacol. 2004 Jan;141(1):114-22. DOI:10.1038/sj.bjp.0705581 |
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