| Identification | Back Directory | [Name]
5H-Thiazolo[3,2-a]pyrimidine-6-carboxylic acid, 3,5-bis(4-chlorophenyl)-7-phenyl-, ethyl ester, hydrobromide (1:1) | [CAS]
2476559-00-7 | [Synonyms]
Topoisomerase II inhibitor 11
5H-Thiazolo[3,2-a]pyrimidine-6-carboxylic acid, 3,5-bis(4-chlorophenyl)-7-phenyl-, ethyl ester, hydrobromide (1:1) | [Molecular Formula]
C27H21BrCl2N2O2S | [MOL File]
2476559-00-7.mol | [Molecular Weight]
588.34 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1]. | [IC 50]
Topoisomerase II: 2.89 μM (IC50) | [References]
[1] Nemr MTM, et al. New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study. Bioorg Chem. 2020 Oct;103:104134. DOI:10.1016/j.bioorg.2020.104134 |
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