| Identification | Back Directory | [Name]
2-Propenamide, N-[3-[[7,8-dihydro-2-[(4-methoxyphenyl)amino]-5H-thiopyrano[4,3-d]pyrimidin-4-yl]oxy]phenyl]- | [CAS]
2477726-83-1 | [Synonyms]
EGFR-IN-56
2-Propenamide, N-[3-[[7,8-dihydro-2-[(4-methoxyphenyl)amino]-5H-thiopyrano[4,3-d]pyrimidin-4-yl]oxy]phenyl]- | [Molecular Formula]
C23H22N4O3S | [MOL File]
2477726-83-1.mol | [Molecular Weight]
434.51 |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1]. | [IC 50]
EGFRL858R/T790M: 132.1 nM (IC50); EGFRT790M: 541.7 nM (IC50) | [References]
[1] Xiao Z, et al. Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115669. DOI:10.1016/j.bmc.2020.115669 |
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