| Identification | Back Directory | [Name]
Desethylchloroquine diphosphate salt | [CAS]
247912-76-1 | [Synonyms]
Desethyl chloroquine diphosphate
Desethylchloroquine diphosphate salt | [Molecular Formula]
C16H25ClN3O4P | [MDL Number]
MFCD34469969 | [MOL File]
247912-76-1.mol | [Molecular Weight]
389.82 |
| Hazard Information | Back Directory | [Uses]
Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2]. | [in vivo]
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3]. | [IC 50]
Plasmodium; TLRs | [storage]
4°C, protect from light, stored under nitrogen | [References]
[1] Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. PMID:2547293
[2] Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74. DOI:10.3233/JHD-130081
[3] Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. DOI:10.4049/jimmunol.1303276 |
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