| Identification | Back Directory | [Name]
GW 9578 | [CAS]
247923-29-1 | [Synonyms]
GW 9578
GW 9578 Exclusive
KYQNYMXQHLMADB-UHFFFAOYSA-N | [Molecular Formula]
C26H34F2N2O3S | [MDL Number]
MFCD07364004 | [MOL File]
247923-29-1.mol | [Molecular Weight]
492.622 |
| Chemical Properties | Back Directory | [Boiling point ]
641.7±55.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);20.3(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.61(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);5.07(Max Conc. mM) | [form ]
Liquid | [pka]
3.77±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity[1][2]. | [IC 50]
mouse PPARα: 5 nM (EC50); h-PPARα: 50 nM (EC50) | [storage]
Store at -20°C | [References]
[1] P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. DOI:10.1021/jm9903601
[2] Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71. DOI:10.1038/sj.bjp.0705232
[3] Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 DOI:10.1074/jbc.M106908200 |
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BOC Sciences
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www.bocsci.com |
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Boao Pike
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www.biopike.cn |
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