| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2484757-20-0 | [Synonyms]
2H4]-Darolutamide
N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl]-5-[1-hydroxy(1,2,2,2-2H?)ethyl]-1H-pyrazole-3-carboxamide | [Molecular Formula]
C19H19ClN6O2 | [MOL File]
2484757-20-0.mol | [Molecular Weight]
398.85 |
| Hazard Information | Back Directory | [Uses]
Darolutamide-d4 (ODM-201-d4) is deuterium labeled Darolutamide. Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Moilanen AM, et al. Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms toandrogen signaling-directed prostate cancer therapies. Sci Rep. 2015 Jul 3;5:12007. doi: 10.1038/srep12007. DOI:10.1038/srep12007 |
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