| Identification | Back Directory | [Name]
Urea, N-[5-[4-[[bis(2-hydroxyethyl)amino]methyl]-2-thiazolyl]-1-ethyl-1H-indol-3-yl]-N'-[(3-chloro-4-methoxyphenyl)methyl]- | [CAS]
2484811-52-9 | [Synonyms]
ATX inhibitor 15
Urea, N-[5-[4-[[bis(2-hydroxyethyl)amino]methyl]-2-thiazolyl]-1-ethyl-1H-indol-3-yl]-N'-[(3-chloro-4-methoxyphenyl)methyl]- | [Molecular Formula]
C27H32ClN5O4S | [MOL File]
2484811-52-9.mol | [Molecular Weight]
558.09 |
| Hazard Information | Back Directory | [Uses]
ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17?nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1]. | [IC 50]
Autotaxin: 2.17 nM (IC50) | [References]
[1] Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951. DOI:10.1016/j.ejmech.2021.113951 |
|
|