| Hazard Information | Back Directory | [Uses]
Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma[1]. | [in vivo]
PRS-060 (i.t; 2, 10, 50 μg) inhibits IL-13-induced eotaxin-1 expression in the lung and ovalbumin-induced acute allergic inflammation in the humanized mouse[1]. | Animal Model: | Triple-humanized mouse model[1] | | Dosage: | 2, 10, 50 μg/mouse | | Administration: | Intratracheal instillation (i.t) | | Result: | Strongly suppressed acute allergic inflammation indices in triple humanized mice. |
| [References]
[1] Gabriele Matschiner, et al. Elarekibep (PRS-060/AZD1402): a new class of inhaled Anticalin medicine targeting IL-4Ra for T2 endotype asthma. J Allergy Clin Immunol. 2022 Dec 30;S0091-6749(22)02588-X. DOI:10.1016/j.jaci.2022.12.815 |
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TargetMol
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400-821-0310 15002144251 |
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www.targetmol.cn/ |
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