| Identification | Back Directory | [Name]
Azaphen hydrochloride | [CAS]
24853-80-3 | [Synonyms]
Azafen
azaphen
AZAPHENONXAZINE
Azaphen (Pipofezine)
Azaphenonxazine 2HCl
Azaphen hydrochloride
Pipofezin hydrochloride
Pipofezine hydrochloride
2-(4-Methyl-1-piperazinyl)-10-methyl-3,4-diazphenoxazine dihydrochloride
2-(4-Methyl-1-piperazinyl)-10-methyl-3,4-diazaphenoxazine dihydrochloride
5-Methyl-3-(4-methylpiperazin-1-yl)-5H-benzo[b]pyridazino[4,3-e][1,4]oxazine dihydrochloride
5H-Pyridazino[3,4-b][1,4]benzoxazine, 5-methyl-3-(4-methyl-1-piperazinyl)-, hydrochloride (1:2) | [Molecular Formula]
C16H19N5O.2ClH | [MOL File]
24853-80-3.mol | [Molecular Weight]
370.28 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Solid |
| Hazard Information | Back Directory | [Uses]
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.
IC50 Value:
Target: SSRIs
Pipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment of depression. | [Safety Profile]
Poison by ingestion, intravenous,and subcutaneous routes. When heated to decompositionit emits very toxic fumes of HCl and NOx. Anantidepressant. | [References]
[1] Domestic antidepressants. 1. Azaphen By Andreeva, N. I.; Asnina, V. V.; Liberman, S. S. From Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) (2000), 34(5), 237-241.
[2] Shinaev NN, Akzhigitov RG. Azaphen: a return to clinical practice.Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):55-6. PMID:16281382
[3] Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. Azaphen in the treatment of enuresis in children.Psychiatr Pol. 1977 Jan-Feb;11(1):29-33. PMID:557800
[4] Liberman SS, Sharova SA. A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals.Farmakol Toksikol. 1975 Jan-Feb;38(1):29-32. PMID:1112390
[5] Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha). 1974;16(4):245-6. PMID:4450998 |
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