| Identification | Back Directory | [Name]
[1,1'-Biphenyl]-2,2'-diol, 3-[4-morpholinyl(3,4,5-trimethoxyphenyl)methyl]-5,5'-di-2-propen-1-yl- | [CAS]
2486455-03-0 | [Synonyms]
Autophagy inducer 4
[1,1'-Biphenyl]-2,2'-diol, 3-[4-morpholinyl(3,4,5-trimethoxyphenyl)methyl]-5,5'-di-2-propen-1-yl- | [Molecular Formula]
C32H37NO6 | [MOL File]
2486455-03-0.mol | [Molecular Weight]
531.64 |
| Chemical Properties | Back Directory | [Boiling point ]
637.1±55.0 °C(Predicted) | [density ]
1.171±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.47±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing autophagy. Autophagy inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells[1]. | [References]
[1] Xu T, et al. Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy. Eur J Med Chem. 2020;205:112663. DOI:10.1016/j.ejmech.2020.112663 |
|
|