| Identification | Back Directory | [Name]
Acetamide, 2-[(5-amino-4,6-dimethyl-2-pyrimidinyl)oxy]-N-[1-[(2,2-difluorocyclopropyl)methyl]-4-piperidinyl]-N-methyl- | [CAS]
2488762-63-4 | [Synonyms]
FGFR-IN-3
Acetamide, 2-[(5-amino-4,6-dimethyl-2-pyrimidinyl)oxy]-N-[1-[(2,2-difluorocyclopropyl)methyl]-4-piperidinyl]-N-methyl- | [Molecular Formula]
C18H27F2N5O2 | [MOL File]
2488762-63-4.mol | [Molecular Weight]
383.44 |
| Hazard Information | Back Directory | [Uses]
FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-3 shows neuroprotective activity. FGFR-IN-3 can be used for neurodegenerative diseases research[1]. | [in vivo]
FGFR-IN-3 (compound 6) is sufficiently lipophilic (logP = 2.2) to passively permeate across the blood-brain barrier, and further increase in molecular lipophilicity results in boosting MBI (mechanism-based inactivation) activity[1]. | [References]
[1] Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562. DOI:10.1016/j.bmc.2020.115562 |
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