| Identification | Back Directory | [Name]
Acetamide, 2-[(6-chloro-3-pyridazinyl)oxy]-N-[1-[(2,2-difluorocyclopropyl)methyl]-4-piperidinyl]-N-methyl- | [CAS]
2488764-17-4 | [Synonyms]
FGFR-IN-7
Acetamide, 2-[(6-chloro-3-pyridazinyl)oxy]-N-[1-[(2,2-difluorocyclopropyl)methyl]-4-piperidinyl]-N-methyl- | [Molecular Formula]
C16H21ClF2N4O2 | [MOL File]
2488764-17-4.mol | [Molecular Weight]
374.81 |
| Hazard Information | Back Directory | [Uses]
FGFR-IN-7 (compound 17) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-7 shows neuroprotective activity. FGFR-IN-7 improves brain exposure and reduced risk of phospholidosis. FGFR-IN-7 can be used for neurodegenerative diseases research[1]. | [in vivo]
FGFR-IN-7 (compound 17) (1 mg/kg, Orally, once daily for 10 days) significantly enhances recovery of coordinated movement in the in vivo rat acute stroke model[1]. | [References]
[1] Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562. DOI:10.1016/j.bmc.2020.115562 |
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