| Identification | Back Directory | [Name]
PD0176078 | [CAS]
248922-46-5 | [Synonyms]
PD0176078
Pentanamide, N-[4,4-bis(4-fluorophenyl)butyl]-4-methyl-2-(methylamino)-, (2S)- | [Molecular Formula]
C23H30F2N2O | [MDL Number]
MFCD31544397 | [MOL File]
248922-46-5.mol | [Molecular Weight]
388.49 |
| Chemical Properties | Back Directory | [Boiling point ]
541.0±50.0 °C(Predicted) | [density ]
1.083±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
15.57±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PD0176078 is a newly found N-type Calcium channel blocker. | [IC 50]
N-type calcium channel | [References]
[1] Yamamoto T, et al. Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorg Med Chem. 2006 Aug 1;14(15):5333-9. DOI:10.1016/j.bmc.2006.03.040
[2] TakashiYamamoto, et al. Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorg Med Chem. 2006 Aug 1;14(15):5333-9. |
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