| Identification | Back Directory | [Name]
Phenol, 4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]- | [CAS]
2489876-34-6 | [Synonyms]
4-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)phenol
Phenol, 4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]- | [Molecular Formula]
C17H12F3N3O2 | [MDL Number]
MFCD32263449 | [MOL File]
2489876-34-6.mol | [Molecular Weight]
347.29 |
| Hazard Information | Back Directory | [Uses]
PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1[1]. | [References]
[1] Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer Res. 2019 Sep 15;79(18):4744-4753. DOI:10.1158/0008-5472.CAN-19-1236 |
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