| Identification | Back Directory | [Name]
4H-Pyran-4-one, 3-[2-[4-(2-furanylcarbonyl)-1-piperazinyl]ethoxy]-2-methyl- | [CAS]
2490699-44-8 | [Synonyms]
LDHA/PDKs-IN-2
4H-Pyran-4-one, 3-[2-[4-(2-furanylcarbonyl)-1-piperazinyl]ethoxy]-2-methyl- | [Molecular Formula]
C17H20N2O5 | [MOL File]
2490699-44-8.mol | [Molecular Weight]
332.35 |
| Hazard Information | Back Directory | [Uses]
LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1]. | [References]
[1] Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579. DOI:10.1016/j.ejmech.2020.112579 |
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