| Identification | Back Directory | [Name]
2H-Indol-2-one, 5-chloro-1-ethyl-1,3-dihydro-3-hydroxy-3-[1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethenyl]- | [CAS]
2494276-55-8 | [Synonyms]
Antiparasitic agent-5
2H-Indol-2-one, 5-chloro-1-ethyl-1,3-dihydro-3-hydroxy-3-[1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethenyl]- | [Molecular Formula]
C20H16ClN3O3 | [MOL File]
2494276-55-8.mol | [Molecular Weight]
381.81 |
| Hazard Information | Back Directory | [Uses]
Antiparasitic agent-5 (compound 8h) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 2.50 μM. Antiparasitic agent-5 also has certain cytotoxicity against HepG2 (CC50 = 6.78 μM)[1]. | [References]
[1] Fernandes FS, et al. Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids. Eur J Med Chem. 2020;201:112418. DOI:10.1016/j.ejmech.2020.112418 |
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