| Identification | Back Directory | [Name]
(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE | [CAS]
249762-74-1 | [Synonyms]
D-65476
PDGFR Tyrosine Kinase Inhibitor II
PDGF RECEPTOR TYROSINE KINASE INHIBITOR II
[2-(1H-2-INDOLYCARBONYL)-1H-5-INDOLYL]BUTANOATE
[2-(1H-2-INDOLYLCARBONYL)-1H-5-INDOLYL]BUTANOATE
(5-BUTANOATE-1H-2-INDOLYL)(1H-2-INDOLYL)-METHANONE
Butanoic acid, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester | [Molecular Formula]
C21H18N2O3 | [MDL Number]
MFCD06411445 | [MOL File]
249762-74-1.mol | [Molecular Weight]
346.38 |
| Hazard Information | Back Directory | [Uses]
D-65476 is an inhibitor of type Ⅲ receptor tyrosine kinase (Flt3). In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
PDGFR in swiss 3T3 cells''Product competes with ATP.''Reversible: yes''Target IC50: 1.1 μM inhibiting PDGFR in swiss 3T3 cells; 6.2 μ M for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells | [References]
[1] Teller S, et al. Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Leukemia. 2002;16(8):1528-1534. DOI:10.1038/sj.leu.2402630 |
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SynAsst Chemical.
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TargetMol
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