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2498762-42-6

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2498762-42-6 Structure

2498762-42-6 Structure
IdentificationBack Directory
[Name]

4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-4,7-diazaspiro[2.5]oct-7-yl]-6-(methylsulfonyl)-8-nitro-
[CAS]

2498762-42-6
[Synonyms]

Antitubercular agent-32
4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-4,7-diazaspiro[2.5]oct-7-yl]-6-(methylsulfonyl)-8-nitro-
[Molecular Formula]

C22H28N4O5S2
[MOL File]

2498762-42-6.mol
[Molecular Weight]

492.61
Chemical PropertiesBack Directory
[Boiling point ]

711.6±70.0 °C(Predicted)
[density ]

1.57±0.1 g/cm3(Predicted)
[pka]

7.19±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC50=3.9 μM)[1].
[References]

[1] Shi R, et al. Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents. ACS Med Chem Lett. 2022 Mar 10;13(4):593-598. DOI:10.1021/acsmedchemlett.1c00652
2498762-42-6 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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