| Identification | Back Directory | [Name]
4,7-Benzofurandione, 2-acetyl-6-[(4-methoxyphenyl)amino]- | [CAS]
2499491-04-0 | [Synonyms]
STAT3-IN-10
4,7-Benzofurandione, 2-acetyl-6-[(4-methoxyphenyl)amino]- | [Molecular Formula]
C17H13NO5 | [MOL File]
2499491-04-0.mol | [Molecular Weight]
311.29 |
| Hazard Information | Back Directory | [Uses]
STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 μM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis[1]. | [in vivo]
STAT3-IN-10 (A11) (i.p.; 5, 10 mg/kg; once a day, 21 days) inhibits the growth of human xenograft tumor in vivo[1]. | Animal Model: | Five weeks old female BALB/c nude mice (16–18g) bearing inoculation of human breast cancer cells MDA-MB-231[1]. | | Dosage: | 5 and 10 mg/kg | | Administration: | IP, once a day, 21 days | | Result: | Inhibited the growth of human xenograft tumor in vivo without apparent body-weight loss for treated mice and inhibited the levels of p-STAT3 in tumor tissues. |
| [IC 50]
STAT3: 5.18 μM (IC50) | [References]
[1] Kai-Rui Feng, et al. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur J Med Chem. 2020 Sep 1;201:112428. DOI:10.1016/j.ejmech.2020.112428 |
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