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2499664-52-5

2499664-52-5 Structure

2499664-52-5 Structure
IdentificationBack Directory
[Name]

6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole
[CAS]

2499664-52-5
[Synonyms]

6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole
6-Bromo-4-(1-((6-((4,4-dimethylpiperidin-1-yl)methyl)imidazo[1,2-a]pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)-1H-indazole
[Molecular Formula]

C25H27BrN8
[MOL File]

2499664-52-5.mol
[Molecular Weight]

519.44
Chemical PropertiesBack Directory
[density ]

1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[form ]

Solid
[pka]

11.05±0.40(Predicted)
[color ]

Light yellow to brown
Hazard InformationBack Directory
[Uses]

STM3006 is a highly potent, selective, and orally active inhibitor of METTL3 (IC50: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results[1][2].
[References]

[1] Andrew A Guirguis, et al. Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.Cancer Discov. 2023 Oct 5;13(10):2228-2247. DOI:10.1158/2159-8290.CD-23-0007
[2] Brichkina A, et al. Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy. Signal Transduct Target Ther. 2023 Dec 11;8(1):448. DOI:10.1038/s41392-023-01696-x
Spectrum DetailBack Directory
[Spectrum Detail]

6-Bromo-4-[1-[[6-[(4,4-dimethyl-1-piperidinyl)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-1H-1,2,3-triazol-4-yl]-1H-indazole(2499664-52-5)1HNMR
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