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2499713-65-2

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2499713-65-2 Structure

2499713-65-2 Structure
IdentificationBack Directory
[Name]

INDEX NAME NOT YET ASSIGNED
[CAS]

2499713-65-2
[Synonyms]

TbPTR1 inhibitor 1
[Molecular Formula]

C22H21N7O
[MOL File]

2499713-65-2.mol
[Molecular Weight]

399.46
Chemical PropertiesBack Directory
[Melting point ]

206-208 °C
[Boiling point ]

696.6±65.0 °C(Predicted)
[density ]

1.357±0.06 g/cm3(Predicted)
[pka]

5.56±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM)[1].
[References]

[1] P?hner I, et al. Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J Med Chem. 2022 Jun 8. DOI:10.1021/acs.jmedchem.2c00232
2499713-65-2 suppliers list
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Telephone: 15076683720
Website: http://www.cw-bio.com
Company Name: Shandong Dayou Pharmaceutical Research and Development Co., Ltd.  
Telephone: hanfangpharma@126.com 15165037910
Website: hanfangpharma@126.com
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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76896-80-5 55837-20-2 70288-86-7 65-61-2 103-90-2 83905-01-5