| Identification | Back Directory | [Name]
Ethanol, 2-[[[3-[[5-(2-methyl[1,1'-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methyl]amino]- | [CAS]
2499965-12-5 | [Synonyms]
PD-1/PD-L1-IN-14
Ethanol, 2-[[[3-[[5-(2-methyl[1,1'-biphenyl]-3-yl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methyl]amino]- | [Molecular Formula]
C24H24N4O2 | [MOL File]
2499965-12-5.mol | [Molecular Weight]
400.47 |
| Chemical Properties | Back Directory | [Boiling point ]
620.1±65.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.75±0.10(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1]. | [References]
[1] Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65(5):3879-3893. DOI:10.1021/acs.jmedchem.1c01682 |
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