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2502156-12-7

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2502156-12-7 Structure

2502156-12-7 Structure
IdentificationBack Directory
[Name]

LC-2 isomer
[CAS]

2502156-12-7
[Synonyms]

LC-2 isomer
LC 2 Epimer
[Molecular Formula]

C59H71ClFN11O7S
[MOL File]

2502156-12-7.mol
[Molecular Weight]

1132.8
Chemical PropertiesBack Directory
[density ]

1.297±0.06 g/cm3(Predicted)
[solubility ]

DMSO:113.28(Max Conc. mg/mL);100.0(Max Conc. mM)
[pka]

14.07±0.40(Predicted)
Hazard InformationBack Directory
[Description]

LC 2 Epimer is a negative control for LC 2.
[Uses]

LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849[1].
[storage]

Store at -20°C
[References]

[1] Bond MJ, et al. Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs. ACS Cent Sci. 2020 Aug 26;6(8):1367-1375. DOI:10.1021/acscentsci.0c00411
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