| Identification | Back Directory | [Name]
Benzamide, N-[2-(1,4-dihydro-8-hydroxy-3-methyl-1,4-dioxo-2-naphthalenyl)ethyl]- | [CAS]
2503096-50-0 | [Synonyms]
STAT3-IN-11
Benzamide, N-[2-(1,4-dihydro-8-hydroxy-3-methyl-1,4-dioxo-2-naphthalenyl)ethyl]- | [Molecular Formula]
C20H17NO4 | [MOL File]
2503096-50-0.mol | [Molecular Weight]
335.35 |
| Chemical Properties | Back Directory | [Boiling point ]
629.5±55.0 °C(Predicted) | [density ]
1.293±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.75±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers[1]. | [References]
[1] Li N, et al. Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition. Bioorg Chem. 2020 Nov;104:104208. DOI:10.1016/j.bioorg.2020.104208 |
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