| Identification | Back Directory | [Name]
4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride | [CAS]
250580-70-2 | [Synonyms]
Ro 363 hydrochloride
4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride | [Molecular Formula]
C19H26ClNO6 | [MOL File]
250580-70-2.mol | [Molecular Weight]
399.87 |
| Hazard Information | Back Directory | [Uses]
Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3]. | [in vivo]
In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane[1]. | [IC 50]
β adrenergic receptor | [storage]
4°C, stored under nitrogen | [References]
[1] Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-)-Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-)-(1-[3',4'-dihydroxyphenoxy] -2-hydroxy-[3",4"-dimethoxy phenethylamino]-propane)-oxalate (Ro 363). Arzneimittelforschung. 1985;35(3):592-8. PMID:2859864
[2] Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85. DOI:10.1111/j.1476-5381.1980.tb10860.x
[3] Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6(1):9-14. DOI:10.1111/j.1474-8673.1986.tb00625.x |
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