| Identification | Back Directory | [Name]
Sulindac EP Impurity C-d3 (Sulindac Sulfide-d3) | [CAS]
250608-66-3 | [Synonyms]
SulindacEPImpurityC-d3
Sulindac EP Impurity C-d3 (Sulindac Sulfide-d3)
Sulindac EP Impurity C-d3 (Sulindac USP Related Compound C-d3, Sulindac Sulfide-d3) | [Molecular Formula]
C20H17FO2S | [MOL File]
250608-66-3.mol | [Molecular Weight]
340.41 |
| Hazard Information | Back Directory | [Uses]
Sulindac sulfide-d3 is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Takahashi Y, et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem. 2003 May 16;278(20):18664-70. DOI:10.1074/jbc.M301619200 |
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