| Identification | Back Directory | [Name]
Ethanone, 1-[4,5-dihydro-3-[3-(1H-tetrazol-1-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)-1H-pyrazol-1-yl]- | [CAS]
2519631-11-7 | [Synonyms]
COX-2-IN-21
Ethanone, 1-[4,5-dihydro-3-[3-(1H-tetrazol-1-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)-1H-pyrazol-1-yl]- | [Molecular Formula]
C21H22N6O4 | [MOL File]
2519631-11-7.mol | [Molecular Weight]
422.44 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-21 (Compound 5c) is a selective and orally active COX-2 inhibitor with an IC50 of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential[1]. | [IC 50]
COX-2: 0.039 μM (IC50); COX-1: 12.4 μM (IC50) | [References]
[1] Labib MB, et al. Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study. Bioorg Chem. 2020 Nov;104:104308. DOI:10.1016/j.bioorg.2020.104308 |
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