| Identification | Back Directory | [Name]
Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl- | [CAS]
251994-14-6 | [Synonyms]
CAM-IN-1
ICAM-1 inhibitor 1
Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl- | [Molecular Formula]
C15H11BrN2O2S | [MOL File]
251994-14-6.mol | [Molecular Weight]
363.23 |
| Chemical Properties | Back Directory | [Melting point ]
78-80 °C | [Boiling point ]
579.6±45.0 °C(Predicted) | [density ]
1.556±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 135 mg/mL (371.67 mM) | [form ]
Solid | [pka]
13.70±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively. | [in vivo]
ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed[1]. | [storage]
Store at -20°C | [References]
[1] Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87. DOI:10.1021/jm0101702 |
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BOC Sciences
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https://www.bocsci.com |
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