| Identification | Back Directory | [Name]
Ceftobiprole Medocaril Sodium Sterile Powder | [CAS]
252188-71-9 | [Synonyms]
CEFTOBIPROLE MEDOCARIL SODIUM
Ceftobiprole medocaril sodium
Ceftobiprole Medocaril Sodium Sterile Powder
Sodium (6R,7R)-3-((E)-(1-((R)-1-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)pyrrolidin-3-yl)-2-oxopyrrolidin-3-ylidene)methyl)-7-((Z)-2-(5-amin | [EINECS(EC#)]
607-653-6 | [Molecular Formula]
C26H27N8NaO11S2 | [MOL File]
252188-71-9.mol | [Molecular Weight]
714.66 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture and light | [solubility ]
DMSO : 250 mg/mL (350.81 mM; Need ultrasonic) | [form ]
Solid | [color ]
Off-white to light yellow | [InChIKey]
UKULSYNDTFCVEY-ATILTDJWNA-N | [SMILES]
C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3=NSC(N)=N3)=N\O)C(=O)N12)/C=C1\CCN([C@@H]2CCN(C(=O)OCC3=C(OC(=O)O3)C)C2)C\1=O)(=O)O.[NaH] |&1:5,7,28,r| |
| Hazard Information | Back Directory | [Uses]
Broad spectrum antibiotic. | [Clinical Use]
#N/A | [in vivo]
Ceftobiprole medocaril (s.c.; 3 × q12h; total daily doses of BAL9141 equivalents, 2.1, 4.2, or 8.4 mg/kg) causes ten-day cumulative survival rates ranged from 57 to 100% for female Swiss albino mice (body weight, 20 to 22 g) infected Penr Cros Ctxs strain P-15986[1].
Ceftobiprole medocaril (10, 40, 160 mg/kg; single dose; sc) has T1/2s from 20 min to 31 min, as the dose rose from 40 mg/kg to 160 mg/kg. The AUC/dose values for the escalating single doses ranges from 0.585 to 1.33, and the Cmax/dose values decreases from 1.08 to 0.90 in neutropenic thigh-infected mice[2].
| [Drug interactions]
Potentially hazardous interactions with other drugs
Anticoagulants: effects of coumarins may be
enhanced.
| [Metabolism]
Ceftobiprole medocaril sodium is the pro-drug of
the active moiety ceftobiprole. Conversion from the
prodrug ceftobiprole medocaril sodium, to the active
moiety ceftobiprole, occurs rapidly and is mediated by
non-specific plasma esterases. Ceftobiprole undergoes
minimal metabolism to the open-ring metabolite, which is
microbiologically inactive |
|
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
|