| Identification | Back Directory | [Name]
2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole | [CAS]
252212-58-1 | [Synonyms]
GAPDH inhibitor compound F8
2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole
1,3,4-Oxadiazole, 2,5-bis[3-(2-oxiranylmethoxy)phenyl]- | [Molecular Formula]
C20H18N2O5 | [MOL File]
252212-58-1.mol | [Molecular Weight]
366.37 |
| Chemical Properties | Back Directory | [Boiling point ]
584.4±58.0 °C(Predicted) | [density ]
1.318±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml | [pka]
-5.20±0.45(Predicted) |
| Hazard Information | Back Directory | [Uses]
GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine[1]. | [References]
[1] Jung Y, et al. Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe. ACS Chem Biol. 2022 Feb 18;17(2):340-347. DOI:10.1021/acschembio.1c00824 |
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