| Identification | Back Directory | [Name]
1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1,1-dipentyl-3-(5-phenyl-1H-imidazol-2-yl)-, (3R)- | [CAS]
252278-73-2 | [Synonyms]
674
BN 81674
BN-81,674
1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1,1-dipentyl-3-(5-phenyl-1H-imidazol-2-yl)-, (3R)- | [Molecular Formula]
C30H38N4 | [MOL File]
252278-73-2.mol | [Molecular Weight]
454.65 |
| Hazard Information | Back Directory | [Uses]
BN-81674 is a somatostatin analogue and a selective antagonist of the non-peptide human somatostatin sst3 receptor (Ki=0.92 nM). In addition, BN-81674 reversed the inhibition of cyclic AMP accumulation induced by 1 nM somatostatin through the sst3 receptor with an IC50 value of 0.84 nM. BN-81674 can be used in cancer research[1]. | [IC 50]
SSTR3: 0.92 nM (Ki) | [References]
[1] Poitout L, et al. Identification of potent non-peptide somatostatin antagonists with sst3 selectivity[J]. Journal of medicinal chemistry, 2001, 44(18): 2990-3000. DOI:10.1021/jm0108449 |
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