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252351-95-4

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252351-95-4 Structure

252351-95-4 Structure
IdentificationBack Directory
[Name]

Lucidadiol
[CAS]

252351-95-4
[Synonyms]

Lucidadiol
Ganoderon B
3,26-Dihydroxylanosta-8,24-dien-7-one
Lanosta-8,24-dien-7-one, 3,26-dihydroxy-, (3β,24E)-
[Molecular Formula]

C30H48O3
[MOL File]

252351-95-4.mol
[Molecular Weight]

456.7
Chemical PropertiesBack Directory
[Melting point ]

163-165℃
[Boiling point ]

569.8±50.0 °C(Predicted)
[density ]

1.07±0.1 g/cm3(Predicted)
[pka]

14.85±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC50 values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1[1][2].
[IC 50]

AChE: 31.03 μM (IC50); BChE: 156.27 μM (IC50)
[References]

[1] Iksoo Lee, et al. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7. DOI:10.1016/j.bmcl.2011.04.042
[2] Lee I,et al. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum [published correction appears in Bioorg Med Chem Lett. 2013 Nov 15;23(22):6199-200]. Bioorg Med Chem Lett. 2011;21(21):6603-6607. DOI:10.1016/j.bmcl.2011.04.042
[3] Mothana RA,et al. Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi. Fitoterapia. 2003;74(1-2):177-180. DOI:10.1016/s0367-326x(02)00305-2
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