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252555-01-4

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252555-01-4 Structure

252555-01-4 Structure
IdentificationBack Directory
[Name]

(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
[CAS]

252555-01-4
[Synonyms]

ACOLBIFENE (hydrochloride)
BYQDPIXWTVEVEA-JMAPEOGHSA-N
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-2H-chromen-7-ol
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol,hydrochloride
[Molecular Formula]

C29H31NO4
[MDL Number]

MFCD32645228
[MOL File]

252555-01-4.mol
Chemical PropertiesBack Directory
[solubility ]

DMSO: 180 mg/mL (364.36 mM)
[form ]

Solid
[color ]

White to yellow
Hazard InformationBack Directory
[Uses]

Prevention or treatment of breast and uterine proliferation or cancer.
[in vivo]

Acolbifene (ACOL) reduces food intake and strongly decreases cholesterolemia in rats fed a cholesterol-free diet[2].
Acolbifene (ACOL) reduces food intake (16%) and weight gain (45%, mainly fat) similarly in both dietary cohorts[2].

Animal Model:Female Sprague-Dawley rats (n = 42) initially weighing 175-200 g[2].
Dosage:2.5 mg/kg.
Administration:Oral gavage, once daily for 21 d.
Result:Prevents tumor growth in rats.
[IC 50]

ERα: 2 nM (IC50, E2-induced transcriptional activity); ERβ: 0.4 nM (IC50, E2-induced transcriptional activity)
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