| Identification | Back Directory | [Name]
Imidazo[1,2-a]pyrazin-3-amine, N-cyclohexyl-2-phenyl- | [CAS]
252725-86-3 | [Synonyms]
WAY-327512
Imidazo[1,2-a]pyrazin-3-amine, N-cyclohexyl-2-phenyl- | [Molecular Formula]
C18H20N4 | [MOL File]
252725-86-3.mol | [Molecular Weight]
292.38 |
| Hazard Information | Back Directory | [Uses]
CDK9-IN-34 (Compound 1b) is an inhibitor for CDK9 with an IC50 of 0.25 μM. CDK9-IN-34 exhibits cytotoxicity to cancer cell HCT116, MCF7 and K652 with IC50 of 1.43, 3.01 and 50.27 μM, respectively. CDK9-IN-34 exhibits antiviral activity against coronavirus 229E with an IC50 of 145.92 μM[1]. | [IC 50]
CDK9: 0.25 μM (IC50) | [References]
[1] Alsfouk AA, et al., Synthesis and Biological Evaluation of Imadazo[1,2-a]pyrazines as Anticancer and Antiviral Agents through Inhibition of CDK9 and Human Coronavirus. Pharmaceuticals (Basel). 2022 Jul 13;15(7):859. DOI:10.3390/ph15070859 |
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