| Identification | Back Directory | [Name]
1H-1,2,4-Triazole-3-carboxamide, 5-cyclopropyl-1-(2,4-dichlorophenyl)-N-1-piperidinyl- | [CAS]
2527805-39-4 | [Synonyms]
CB1-IN-2
1H-1,2,4-Triazole-3-carboxamide, 5-cyclopropyl-1-(2,4-dichlorophenyl)-N-1-piperidinyl- | [Molecular Formula]
C17H19Cl2N5O | [MOL File]
2527805-39-4.mol | [Molecular Weight]
380.27 |
| Hazard Information | Back Directory | [Uses]
CB1-IN-2 (Compound 4g) is a selective CB1 inhibitor with an IC50 of 0.644 μM. CB1-IN-2 can penetrates BBB and might cause CNS side effect similar with Rimonabant[1]. | [IC 50]
CB1: 0.644 μM (IC50) | [References]
[1] Tsai SE, et al. Chlorotrimethylsilane promoted one-flask heterocyclic synthesis of 1,2,4-triazoles from nitrilimines: Modeling studies and bioactivity evaluation of LH-21 and Rimonabant analogues. Bioorg Chem. 2020 Nov;104:104299. DOI:10.1016/j.bioorg.2020.104299 |
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