| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- | [CAS]
2529891-44-7 | [Synonyms]
EGFR-IN-59
Benzenesulfonamide, 4-[[2-[(1E)-2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]amino]-N-(5-methyl-3-isoxazolyl)- | [Molecular Formula]
C27H23N5O4S | [MOL File]
2529891-44-7.mol | [Molecular Weight]
513.57 |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 μM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer[1]. | [References]
[1] Noha H Amin, et al. Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers. Bioorg Chem. 2020 Dec;105:104358. DOI:10.1016/j.bioorg.2020.104358 |
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