| Identification | Back Directory | [Name]
R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE | [CAS]
253446-15-0 | [Synonyms]
R(+)-SKF-81297
R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE
(5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | [Molecular Formula]
C16H16ClNO2.BrH | [MDL Number]
MFCD00671792 | [MOL File]
253446-15-0.mol | [Molecular Weight]
370.672 |
| Chemical Properties | Back Directory | [solubility ]
H2O: soluble6mg/mL | [form ]
solid | [color ]
white to off-white | [Optical Rotation]
[α]22/D +15.14°, c = 0.52 in DMF(lit.) | [Water Solubility ]
H2O: 6mg/mL
DMSO: soluble | [InChI]
1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1 | [InChIKey]
RMIJGBMRNYUZRG-BTQNPOSSSA-N | [SMILES]
Br[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3 |
| Hazard Information | Back Directory | [Uses]
R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:
- to test it effect on the spike firing in rat retinal ganglion cells
- in human embryonic kidney (HEK) 293T cells
- to test its inhibitory effect in microglial cells
| [Uses]
R(+)-SKF-81297 Hydrobromide is a dopamine D1 agonist. | [Biochem/physiol Actions]
SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons. |
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