| Identification | Back Directory | [Name]
2-AMINO-3-IODO-5-NITROPYRIDINE | [CAS]
25391-56-4 | [Synonyms]
3-IODO-5-NITROPYRIDIN-2-AMINE
3-iodo-5-nitro-2-pyridinamine
2-AMINO-3-IODO-5-NITROPYRIDINE
2-Pyridinamine, 3-iodo-5-nitro-
3-Iodo-5-nitro-pyridin-2-ylamine
2-AMINO-3-IODO-5-NITROPYRIDINE ISO 9001：2015 REACH | [Molecular Formula]
C5H4IN3O2 | [MDL Number]
MFCD07368863 | [MOL File]
25391-56-4.mol | [Molecular Weight]
265.01 |
| Chemical Properties | Back Directory | [Melting point ]
231-236 °C | [Boiling point ]
391.7±42.0 °C(Predicted) | [density ]
2.229±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
0.41±0.49(Predicted) | [Appearance]
Light yellow to yellow Solid | [InChI]
1S/C5H4IN3O2/c6-4-1-3(9(10)11)2-8-5(4)7/h1-2H,(H2,7,8) | [InChIKey]
FEADVZZIWYNCBF-UHFFFAOYSA-N | [SMILES]
Nc1ncc(cc1I)[N+]([O-])=O |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-36/37/38-43 | [Safety Statements ]
26-36/37 | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
Useful starter in azaindole chemistry. | [Synthesis]
General procedure for the synthesis of 2-amino-3-iodo-5-nitropyridine from 2-amino-5-nitropyridine: 5-nitropyridin-2-amine (14 g, 100 mmol), potassium iodide (16.6 g, 100 mmol) and potassium iodate (10.7 g, 50 mmol) were dissolved in dilute sulfuric acid (2 N, 200 mL). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the pH was adjusted slowly by adding sodium hydroxide solution (5 N, 80 mL) to about 10. The resulting solid product was collected by filtration, washed sequentially with deionized water and ethanol and finally dried under vacuum. The target compound 2-amino-3-iodo-5-nitropyridine (25 g, 94% yield) was obtained. The structure of the product was characterized by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 6.80-8.40 (br s, 2H), 8.57 (d, J = 2.4 Hz, 1H), 8.84 (d, J = 2.4 Hz, 1H); MS (ESI) m/z 264 [M+H]+. | [References]
[1] Synthesis, 2005, # 15, p. 2503 - 2506
[2] Patent: WO2010/32, 2010, A1. Location in patent: Page/Page column 78-79
[3] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 14, p. 3853 - 3860
[4] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 56-57
[5] Organic Process Research and Development, 2015, vol. 19, # 9, p. 1282 - 1285 |
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