| Identification | Back Directory | [Name]
3-Piperidinecarboxamide, N-cyclohexyl-4-[[5-(2-furanyl)-1,2-dihydro-3-methyl-2-oxo-1,7-naphthyridin-8-yl]amino]-1-methyl-, (3R,4R)- | [CAS]
2540591-06-6 | [Synonyms]
GSK789
3-Piperidinecarboxamide, N-cyclohexyl-4-[[5-(2-furanyl)-1,2-dihydro-3-methyl-2-oxo-1,7-naphthyridin-8-yl]amino]-1-methyl-, (3R,4R)- | [Molecular Formula]
C26H33N5O3 | [MOL File]
2540591-06-6.mol | [Molecular Weight]
463.57 |
| Hazard Information | Back Directory | [Description]
GSK789 is a selective inhibitor of the first bromodomains (BD1) of the bromo and extra terminal domain (BET) proteins. | [Uses]
GSK789 is an effective, cell-permeable, and highly selective inhibitor of the BET family first bromodomain (BD1), with antitumor and immunomodulatory effects[1] | [References]
[1] Watson RJ, et al. GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. J Med Chem. 2020 Sep 10;63(17):9045-9069. DOI:10.1021/acs.jmedchem.0c00614 |
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