2540915-70-4

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2540915-70-4 Structure

Identification	Back Directory
[Name] NHTD
[CAS] 2540915-70-4
[Synonyms] NHTD Benzoic acid, 2,4-dihydroxy-, (2E)-2-[[3-(1,1-dimethylethyl)-6,7,8,9-tetrahydro-2-hydroxy-1-dibenzofuranyl]methylene]hydrazide
[Molecular Formula] C24H26N2O5
[MOL File] 2540915-70-4.mol
[Molecular Weight] 422.47

Chemical Properties	Back Directory
[density ] 1.352±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 8.005±0.35(predicted)

Hazard Information	Back Directory
[Uses] NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC)[1].
[IC 50] K-RAS
[References] [1] Leung EL, et al. Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer. Int J Cancer. 2019 Sep 1;145(5):1334-1345. DOI:10.1002/ijc.32222

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