| Identification | Back Directory | [Name]
2-(3-sulfanylpropyl)pentanedioic acid | [CAS]
254737-29-6 | [Synonyms]
2-MPPA
FNLNSQHJKVQCBP-UHFFFAOYSA-N
2-(3-Mercaptopropyl)pentanedioic acid
2-(3-sulfanylpropyl)pentanedioic acid
Pentanedioic acid, 2-(3-mercaptopropyl)- | [Molecular Formula]
C8H14O4S | [MOL File]
254737-29-6.mol | [Molecular Weight]
206.26 |
| Chemical Properties | Back Directory | [Melting point ]
51-53 °C | [Boiling point ]
377.124±32.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.256±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in water and to 100 mM in DMSO | [form ]
Powder | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
2-MPPA is a selective glutamate carboxypeptidase II (GCP-II) inhibitor used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties. | [in vivo]
2-MPPA (10, 30 or 100 mg/kg) significantly attenuates Dizocilpine (HY-15084B) (0.1 mg/kg)-induced prepulse inhibition (PPI) deficits in mice, in a dose dependent manner. The efficacy of 2-MPPA on dizocilpine-induced PPI deficits is significantly antagonized by pretreatment with the selective group II metabotropic glutamate receptor (mGluR) antagonist LY341495 (HY-70059) (1.0 mg/kg)[1].
2-MPPA (30 mg/kg) significantly prevents the deficit in SNCV induced by both 5 and 25 mg/kg taxol by 96.3 ± 4.4% and 98.3± 11.6% respectively[2].
2-MPPA (10 mg/kg) inhibits tumor growth in the high expressor PSMA model CWR22RS by 70%[2]. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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