| Identification | Back Directory | [Name]
Clindamycin palmitate hydrochloride | [CAS]
25507-04-4 | [Synonyms]
Clindmycin
Cleocin Pediatric
CLINDAMYCIN PALMITATE HCL
Clindamycin 2-Palmitate HCl
ClindaMycin PalMitate HCl USP
Clindamycin Hydrochloride Palmitate
Clindamycin palmitate hydrochloride
clindamycin2’-palmitatehydrochloride
Clindamycin Palmitate Hydrochloride (USP)
Clindmycin palmitate hydrochloride USP/EP/BP
Clindamycin Palmitate Hydrochloride (500 mg)
Clindamycin palmitate hydrochloride USP/EP/BP
Clindamycin Palmitate Hydrochloride (500 mg)G0D334586ug/mg(an)
hexadecanoic acid [6-[2-chloro-1-[[(1-methyl-4-propyl-2-pyrrolidinyl)-oxomethyl]amino]propyl]-4,5-dihydroxy-2-(methylthio)-3-oxanyl] ester
Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-hexadecanoatemonohydrochloride
Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl] carbonyl]amino]-1-thio-L-threo-α-D-galactooctopyranoside 2-Hexadecanoate Monohydrochloride
methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- 2-hexadecanoate-L-threo-α-D-galacto-octopyranoside,monohydrochloride | [EINECS(EC#)]
607-740-9 | [Molecular Formula]
C34H64Cl2N2O6S | [MDL Number]
MFCD03093716 | [MOL File]
25507-04-4.mol | [Molecular Weight]
699.85 |
| Chemical Properties | Back Directory | [Melting point ]
141-143°C | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChIKey]
GTNDZRUWKHDICY-ZLNNALEKSA-N | [SMILES]
[C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](OC(=O)CCCCCCCCCCCCCCC)[C@@H](SC)O1)O)([C@@H](Cl)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,26,31,36,39,r| |
| Hazard Information | Back Directory | [Description]
Clindamycin palmitate is a water-soluble prodrug form of the antibiotic clindamycin (Item No. 15006).1 It undergoes rapid hydrolysis in vivo to release active clindamycin. Formulations containing clindamycin palmitate have been used in the treatment of various bacterial infections. | [Chemical Properties]
White Solid | [Uses]
antibacterial (tuberculostatic) | [Uses]
Clindamycin Palmitate is a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial. | [Definition]
ChEBI: Clindamycin palmitate hydrochloride is a S-glycosyl compound. | [Brand name]
Cleocin (Pharmacia & Upjohn). | [General Description]
Clindamycin palmitate hydrochloride (Cleocin Pediatric) isthe hydrochloride salt of the palmitic acid ester ofcleomycin. The ester bond is to the 2-hydroxyl group of thelincosamine sugar. The ester serves as a tasteless prodrugform of the antibiotic, which hydrolyzes to clindamycin inthe plasma. The salt form confers water solubility to theester, which is available as granules for reconstitution intoan oral solution for pediatric use. Although absorption of thepalmitate is slower than that of the free base, there is littledifference in overall bioavailability of the two preparations.Reconstituted solutions of the palmitate hydrochloride arestable for 2 weeks at room temperature. Such solutionsshould not be refrigerated because thickening occurs thatmakes the preparation difficult to pour. | [storage]
Store at -20°C | [References]
[1] CH. BHARATHI . Identification, isolation and characterization of impurities of clindamycin palmitate hydrochloride[J]. Journal of pharmaceutical and biomedical analysis, 2008, 48 4: Pages 1211-1218. DOI: 10.1016/j.jpba.2008.08.011 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Aemon Chemical
|
| Telephone: |
0086-755-86198205 |
| Website: |
www.aemonchem.com |
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