| Identification | Back Directory | [Name]
26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)- | [CAS]
2553218-46-3 | [Synonyms]
26,27-Dinorcholestan-24-one, 25-fluoro-7-hydroxy-3-(sulfooxy)-, sodium salt (1:1), (3α,5β,7α)- | [Molecular Formula]
C25H42FNaO6S | [MDL Number]
MFCD32857161 | [MOL File]
2553218-46-3.mol | [Molecular Weight]
512.65 |
| Hazard Information | Back Directory | [Uses]
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1]. | [Biological Activity]
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1].
BSH Inhibitor Gut restricted-7 (GR-7) (60 μM) does not affect epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic. Gut restricted-7 also does not affect microbial biomass[1].
The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (GR-7) (w/w) for 1 d day or powdered chow alone. Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitortreated mice 8 h postdiet change. 20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected[1]. | [in vivo]
The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (GR-7) (w/w) for 1 d day or powdered chow alone. Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitortreated mice 8 h postdiet change. 20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected[1]. | [References]
[1]. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 Mar;16(3):318-326. |
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