| Identification | Back Directory | [Name]
Artemifone | [CAS]
255730-18-8 | [Synonyms]
Artemisone
Artemifone
BAY 44-9585
YHVQDGXHTCSGBJ-AKSSTEKGSA-N
10alpha-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-deoxodihydroartemisinin
4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]thiomorpholine 1,1-dioxide
Thiomorpholine, 4-[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]-, 1,1-dioxide | [Molecular Formula]
C19H31NO6S | [MDL Number]
MFCD13182370 | [MOL File]
255730-18-8.mol | [Molecular Weight]
401.52 |
| Chemical Properties | Back Directory | [Boiling point ]
536.5±50.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 130 mg/mL (323.77 mM) | [form ]
Solid | [pka]
2.99±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM[1]. Artemisone is also a potent inhibitor of human CMV[2]. | [in vivo]
Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED50 of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration[1].
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS[1] | [IC 50]
Plasmodium | [References]
[1] Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59(4):658-65. DOI:10.1093/jac/dkl563
[2] Ruiyuan Cao, et al. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect. Dis. 2020 Jul. |
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