| Identification | Back Directory | [Name]
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(2R)-3-[(1S)-1-hydroxy-2-[3-(trifluoromethyl)phenoxy]ethyl]-2-oxiranyl]cyclopentyl]-, 1-methylethyl ester, (5Z)- | [CAS]
2557327-99-6 | [Synonyms]
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(2R)-3-[(1S)-1-hydroxy-2-[3-(trifluoromethyl)phenoxy]ethyl]-2-oxiranyl]cyclopentyl]-, 1-methylethyl ester, (5Z)- | [Molecular Formula]
C26H35F3O7 | [MOL File]
2557327-99-6.mol | [Molecular Weight]
516.55 |
| Chemical Properties | Back Directory | [Boiling point ]
619.6±55.0 °C(Predicted) | [density ]
1.282±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | [pka]
13.48±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Fluprostenol isopropyl ester is a potent F-series prostaglandin receptor agonist that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma.1,2 13,14-epoxy Fluprostenol isopropyl ester is an impurity generated in the production of fluprostenol isopropyl ester. This product is a 4:96 diastereomeric mixture of epoxides. | [Uses]
13,14-epoxy Travoprost (13,14-epoxy Fluprostenol isopropyl ester) is a mixture of diastereomeric epoxides generated during production of Travoprost (HY-B0584). Travoprost is a selective agonist for prostaglandin F receptor, which exhibits an ocular hypotensive efficacy[1]. | [References]
1. Sorbera, L.A., and Casta?er, J. Travoprost Drugs Future 25(1),41-45(2000).
2. Hellberg, M.R., Sallee, V.L., McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist J. Ocul. Pharmacol. Ther. 17(5),421-432(2001). |
|
| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
|