| Identification | Back Directory | [Name]
MCA-PRO-BETA-CYCLOHEXYL-ALA-GLY-NVA-HIS-ALA-DAP(DNP)-NH2 | [CAS]
256394-94-2 | [Synonyms]
Mca-Pro-β-cyclohexyl-AG-Nva-HA-Dap(Dnp)-NH2
Mca-Pro-b-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH2
MCA-PRO-β-CYCLOHEXYL-ALA-GLY-NVA-HIS-ALA-DAP(DNP)-NH2
MCA-PRO-BETA-CYCLOHEXYL-ALA-GLY-NVA-HIS-ALA-DAP(DNP)-NH2
Mca-Pro-β-cyclohexyl-Ala-Gly-Nva-His-Ala-Dap(Dnp)-NH? trifluoroacetate salt
1-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-3-cyclohexyl-L-alanylglycyl-L-norvalyl-L-histidyl-L-alanyl-3-[(2,4-dinitrophenyl)amino]-L-alaninamide
L-Alaninamide, 1-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-3-cyclohexyl-L-alanylglycyl-L-norvalyl-L-histidyl-L-alanyl-3-[(2,4-dinitrophenyl)amino]- | [Molecular Formula]
C51H65N13O15 | [MDL Number]
MFCD05663487 | [MOL File]
256394-94-2.mol | [Molecular Weight]
1100.14 |
| Hazard Information | Back Directory | [Description]
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. 7-methoxycoumarin-4-acetyl (Mca) is released by cleavage of Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2, of which the fluorescence can be used to quantify MMP-1, MMP-3 and MMP-26 activity. | [Uses]
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity[1][2]. | [IC 50]
MMP-1; MMP-3; MMP-26 | [References]
[1] Park HI, et al. Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. J Biol Chem. 2002 Sep 20;277(38):35168-75. DOI:10.1074/jbc.M205071200
[2] Kn?uper V, et al. The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. Eur J Biochem. 2001 Mar;268(6):1888-96. PMID:11248710 | [Sequene]
Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-NH2 |
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