| Identification | Back Directory | [Name]
O-METHYLDOMESTICINE | [CAS]
2565-01-7 | [Synonyms]
nantenine
Domestine
O-METHYLDOMESTICINE
ORTHO-METHYLDOMESTICINE
(6aS)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6-methyl-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline | [Molecular Formula]
C20H21NO4 | [MDL Number]
MFCD01664593 | [MOL File]
2565-01-7.mol | [Molecular Weight]
339.39 |
| Hazard Information | Back Directory | [Description]
This alkaloid has been isolated from the seeds of Nandina domestica L. and, more
recently, from Cassytha filiformis. The base is dextrorotatory with [Q]b8 + 101°
(CHC13). An aporphine alkaloid, two methoxy1 groups and one methy1enedioxy
group are present. The optically inactive base is identical with Thalictruberine
(q.v.). | [Uses]
Nantenine is a serotonergic receptor antagonist. Nantenine selectively inhibits the contractile response of tissues to serotonin. Nantenine can be isolated from Nandina domestica[1]. | [Definition]
ChEBI: A natural product found in Corydalis cava and Nandina domestica. | [References]
Fujita, Tomimatsu., J. Pharm. Soc., Japan, 79, 1252 (1959)
Kitamura., ibid, 80, 219, 613 (1960)
Synthesis:
Merchant, Desai.,Ind. J. Chem., 11,342 (1973) |
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