| Identification | Back Directory | [Name]
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) | [CAS]
256519-11-6 | [Synonyms]
2-Chloro-4-fluorobenzimidazole
2-Chloro-4-fluoro-1H-benzimidazole
1H-Benzimidazole, 2-chloro-7-fluoro-
1H-BENZIMIDAZOLE, 2-CHLORO-4-FLUORO-
2-chloro-4-fluoro-1H-1,3-benzodiazole
2-Chloro-7-fluoro-1H-benzo[d]imidazole
2-Chloro-4-fluoro-1H-benzo[d]imidazole
1H-Benzimidazole,2-chloro-4-fluoro-(9CI) | [Molecular Formula]
C7H4ClFN2 | [MDL Number]
MFCD17214991 | [MOL File]
256519-11-6.mol | [Molecular Weight]
170.57 |
| Chemical Properties | Back Directory | [Boiling point ]
332.9±34.0 °C(Predicted) | [density ]
1.533±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
7.60±0.30(Predicted) |
| Questions And Answer | Back Directory | [Uses]
2-Chloro-4-fluoro-(9CI)-1H-benzimidazole is a pharmaceutical intermediate that can be obtained by first preparing 4-fluoro-1H-benzimidazole-2(3H)-one from 3-fluorophenyl-1,2-diamine, followed by chlorination. It has been reported in the literature that it can be used to prepare ATR kinase inhibitors. | [Application]
2-Chloro-4-fluoro-(9CI)-1H-benzimidazole can be used to prepare 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine and 4-fluoro-N-methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonylimino)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazole-2-amine. These two compounds have important applications in the treatment of proliferative diseases (such as cancer), particularly in diseases mediated by ataxia-telangiectasia mutations and RAD-3-related protein kinase inhibitors (commonly known as ATRs). |
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SynAsst Chemical.
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Cochemical Ltd.
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http://www.cochemical.com |
| Company Name: |
Cochemical Ltd.
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| Tel: |
029-86115547 17791676824 |
| Website: |
http://www.cochemical.com |
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