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2565637-94-5

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2565637-94-5 Structure

2565637-94-5 Structure
IdentificationBack Directory
[Name]

AB25583
[CAS]

2565637-94-5
[Synonyms]

AB25583
[Molecular Formula]

C22H17ClN4O3S
[MOL File]

2565637-94-5.mol
[Molecular Weight]

452.92
Chemical PropertiesBack Directory
[density ]

1.400±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

6.276±0.10(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research[1].
[References]

[1] Ito F, et al. Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 Aug 14;15(1):7003. DOI:10.1038/s41467-024-51351-4
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