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2565657-20-5

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2565657-20-5 Structure

2565657-20-5 Structure
IdentificationBack Directory
[Name]

LSN3353871
[CAS]

2565657-20-5
[Synonyms]

LSN3353871
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

LSN3353871 is a potent inhibitor of lipoprotein(a) (Lp(a)) that can binds to Kringle IV (KIV) 8, KIV7–8 and KIV5–8, with Kd of 756?nM, 605?nM and 423?nM, respectively. LSN3353871 disrupts the formation of Lp(a) with the IC50 of 1.69?μM. LSN3353871 has oral bioactivity[1].
[References]

[1] Nuria Diaz, et al. Discovery of potent small-molecule inhibitors of lipoprotein(a) formation. Nature. 2024 May;629(8013):945-950. DOI:10.1038/s41586-024-07387-z
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